Recombinant human RBM4 protein,BR

基因名： RBM4
别名： dkfzp547k0918;hLark;lark;Lark homolog;lark homologue;mgc75138;RBM4;rbm4 lark;RBM4_HUMAN;RNA binding motif 4;RNA binding motif 4a;RNA-binding motif protein 4;RNA-binding motif protein 4a;RNA-binding protein 4;
英文名称： Recombinant Human RBM4 Protein
全名： RNA binding motif protein 4
中文名称： RNA结合基序蛋白4
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： Q9BWF3
Gene ID： 5936
交叉反应： Human Mouse Rat (Bovine Pig Rabbit)
分子量： 40kDa
区间范围： 1-364aa
背景说明： RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation.Modulates alternative 5'-splice site and exon selection.Acts as a muscle cell differentiation-promoting factor.Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation.Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin.Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs.Required for the translational activation of PER1 mRNA in response to circadian clock.Binds directly to the 3'-UTR of the PER1 mRNA.Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation.Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress.Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions.Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs.Associates with miRNAs during muscle cell differentiation.Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

暂无数据

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