Recombin human UGCG protein,BR

基因名: UGCG
别名: GLCT-1;GCS;
英文名称: Recombinant human UGCG protein
全名: UDP-glucose ceramide glucosyltransferase
中文名称: UDP-葡萄糖神经酰胺葡萄糖基转移酶
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

Swiss Prot： Q16739
Gene ID： 7357
交叉反应： Human Mouse Rat
分子量： 28kDa
区间范围： 1-250aa
背景说明： Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer.Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures.Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction.They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions.They are required for instance in the proper development and functioning of the nervous system.As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway.They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope.The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity).
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

暂无数据

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