Recombin human NR0B2 protein,BR

基因名: NR0B2
别名: NR0B2;NR0B2_HUMAN;Nr0b2a;Nuclear receptor subfamily 0 group B member 2;Nuclear receptor subfamily 0，group B，member 2a;Orphan nuclear receptor SHP;SHP;SHP-1;Shp1;Small heterodimer partner;
英文名称: Recombinant human NR0B2 protein
全名: nuclear receptor subfamily 0，group B，member 2
中文名称: 核受体亚家族0,B组成员2
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

Swiss Prot： Q15466
Gene ID： 8431
交叉反应： Human Mouse Rat
分子量： 29kDa
区间范围： 1-257aa
背景说明： Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity).Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity).Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053).Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity).Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity).Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity).
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

暂无数据

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