Recombin human ERH protein,BR

基因名: ERH
别名: ERH;DROER;enhancer of rudimentary homolog
英文名称: Recombinant human ERH protein
全名: enhancer of rudimentary homolog (Drosophila)
中文名称: 同源物增强子
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

Swiss Prot： P84090
Gene ID： 2079
交叉反应： Human Mouse (Bovine Pig Zebrafish A.thaliana)
分子量： 12kDa
区间范围： 1-104aa
背景说明： ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes.ERH may play a role in cell cycle regulation and pyrimidine biosynthesis.ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1).HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD.By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver.The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands.ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH.ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize.
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

暂无数据

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