Recombinant Human IL-36 α/IL-36α/IL-1F6/Interleukin-36 α,BR

别名： IL-36 alpha;IL-36α;Interleukin-36 Alpha;FIL1 Epsilon;Interleukin-1 Epsilon;IL-1 Epsilon;Interleukin-1 Family Member 6;IL-1F6;IL36A;FIL1E;IL1E;IL1F6
英文名称： Recombinant Human IL-36 alpha/IL-36α/IL-1F6/Interleukin-36 alpha
中文名称： 重组人IL-36 alpha/IL-36α/IL-1F6/Interleukin-36 alpha
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 50mM Tris-HCl, 150mM NaCl, 1 mM EDTA, 0.02% Tween 20, pH 8.0.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Lyophilized protein should be stored at ≤ -20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months.
运输条件： 冷藏运输

背景说明： Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family.IL-36α is expressed in the immune system and the fetal brain，but not in other tissues or multiple hematopoietic cell lines.IL-36α is the only IL-1 family member found to be expressed on T-cells.IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression.Importantly，IL-36α inhibits PPARγ expression，which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine.IL-36α，along with IL-1F8 and IL-1F9，has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner.This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation，recruits a second receptor as a signaling component，forming an active heterodimeric receptor complex.
来源： E.coli

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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