Recombinant Human LIM and cysteine-rich domains protein 1/LMCD1/Dyxin,BR

别名： LIM and cysteine-rich domains protein 1;LMCD1;Dyxin
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region.It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site.LMCD1 is expressed in many tissues with highest abundance in skeletal muscle.LMCD1 restricts GATA6 function by inhibiting DNA-binding，resulting in repression of GATA6 transcriptional activation of downstream target genes.It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
来源： E.coli

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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