Recombinant Human Thymidine kinase, cytosolic/TK1,BR

别名： Thymidine kinase;cytosolic;TK1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,1mM DTT,2mM EDTA, 10% Glycerol, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Thymidine kinase 1(TK1) belongs to the thymidine kinase family.It is located in the cytoplasm，and phosphorylated on Ser-13 in mitosis during post-translational modification.Two forms of this protein have been identified in animal cells，one in cytosol TK1 and one in mitochondria TK2.Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division，as they are part of the unique reaction chain to introduce deoxythymidine into the DNA.Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle，while it is very low in resting cells.TK1 acts as a homotetramer，and can transform thymidime to thymidine 5'-phosphate with the help of ATP
来源： Human Cells

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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