Recombinant Human Lymphocyte cytosolic protein 2/LCP2,BR

别名： Lymphocyte cytosolic protein 2;SH2 domain-containing leukocyte protein of 76 kDa;SLP-76 tyrosine phosphoprotein;SLP76;LCP2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 20% Glycerol, pH 8.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain.It is highly expressed in spleen，thymus and peripheral blood leukocytes，T-cell and monocytic cell lines，but expressed at lower level in B-cell lines.LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.It is phosphorylated after T-cell receptor activation by ZAP70，ITK and TXK，which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification.Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
来源： E.coli

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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