Recombinant Human Transthyretin/ATTR,BR

别名： Transthyretin;ATTR;Prealbumin;TBPA;TTR;PALB
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Transthyretin is a secreted and cytoplasm protein which belongs to the Transthyretin family.Transthyretin is detected in serum and cerebrospinal fluid (at protein level).It is highly expressed in choroid plexus epithelial cells.It is also detected in retina pigment epithelium and liver.Each monomer of Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid.Antiparallel beta-sheet interactions link monomers into dimers.A short loop from each monomer forms the main dimer-dimer interaction.These two pairs of loops separate the opposed，convex beta-sheets of the dimers to form an internal channel.Defects in Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to transthyretin amyloid deposition.Protein fibrils can form in different tissues leading to amyloid polyneuropathies，amyloidotic cardiomyopathy，carpal tunnel syndrome，systemic senile amyloidosis.The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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