Recombinant Human CCL26/Eotaxin-3 (24-94),BR

别名： C-C Motif Chemokine 26;CC Chemokine IMAC;Eotaxin-3;Macrophage Inflammatory Protein 4-Alpha;MIP-4-Alpha;Small-Inducible Cytokine A26;Thymic Stroma Chemokine-1;TSC-1;CCL26;SCYA26
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris, 1mM EDTA, 20% Glycerol, pH 9.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes.CCL26 is constitutively expressed in thymus，but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells.It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.CCL26，along with Eotaxin-1 and Eotaxin-2，selectively activates the CC chemokine receptor 3 (CCR3).The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma.The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues.Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line.Unlike most other CC chemokines，CCL26 maps to human chromosome 7q11.2，within 40 kilobases of the Eotaxin-2 loci.CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
来源： E.coli

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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