Recombinant Mouse Exostosin-Like 2/EXTL2,BR

别名： Exostosin-like 2;Extl2;Alpha-1;4-N-acetylhexosaminyltransferase EXTL2;Alpha-GalNAcT EXTL2;EXT-related protein 2;Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1，EXT2，EXTL1，EXTL2，and EXTL3.Studies have shown that EXT gene family members have the activities of heparan sulfate-synthesizing glycosyltransferases.EXT1 and EXT2，which have been identified as causal genes for hereditary multiple exostoses，have HS-GlcAT-II and GlcNAcT-II activities.EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities.EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities，and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation.In mice，lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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