Recombinant Human HO-1/HMOX1/HSP32,BR

别名： Heme Oxygenase 1;HO-1;HMOX1;HO;HO1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family.HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin.Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase.In physiological state，the highest activity of HO-1 is found in the spleen，where senescent erythrocytes are sequestrated and destroyed.HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals，bromobenzene，endotoxin，oxidizing agents and UVA.HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors.Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency，resulting in marked erythrocyte fragmentation and intravascular hemolysis，coagulation abnormalities，endothelial damage，and iron deposition in renal and hepatic tissues.
来源： E.coli

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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