Recombinant Human NGAL/Lipocalin-2/LCN2/Neutrophil gelatinase-associated lipocalin/p25,BR

别名： Neutrophil gelatinase-associated lipocalin;NGAL;25 kDa alpha-2-microglobulin-related subunit of MMP-9;Lipocalin-2;Oncogene 24p3;Siderocalin LCN2;p25;HNL;NGAL
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily.This protein is released from injured tubular cells after various damaging stimuli，is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI).Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions.Moreover，recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases.NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores，which are high-affinity iron chelators.NGAL，first known as an antibacterial factor of natural immunity，and an acute phase protein，is currently one of the most interesting and enigmatic proteins involved in the process of tumor development.acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation，NGAL has a clear pro-tumoral effect，as has already been observed in different tumors (e.g.breast，stomach，oesophagus，brain) in humans.In thyroid carcinomas，NGAL is strongly induced by NF-kB，an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development.Thus，Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation，proliferation，survival and morphogenesis.
来源： E.coli

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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