Recombinant Human Mothers Against Decapentaplegic Homolog 2/SMAD2,BR

别名： Mothers against decapentaplegic homolog 2;MAD homolog 2;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;Hsmad2;SMAD2;MADH2;MADR2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.

背景说明： Mothers against decapentaplegic homolog 2(SMAD2) is a cytoplasm protein which belongs to the dwarfin/SMAD family.Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus.Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases.SMAD2 is contains 1 MH1 (MAD homology 1) domain and1 MH2 (MAD homology 2) domain.It is expressed at high levels in skeletal muscle，endothelial cells，heart and placenta.It binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and，on formation of the SMAD2/SMAD4 complex，activates transcription.It may act as a tumor suppressor in colorectal carcinoma.And SMAD2 positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
来源： E.coli

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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