Recombinant Human Fc gamma RIIB/CD32b,BR

别名： Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b;IgG Fc Receptor II-b;CDw32;Fc-Gamma RII-b;Fc-Gamma-RIIb;FcRII-b;CD32;FCGR2B;FCG2;IGFR2
中文名称: Recombinant Human Fc gamma RIIB/CD32b
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG.The human CD32 group consists of FcγRIIA，FcγRIIB，and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains.FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding.Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis.Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation.FcγRIIB may also be a target for monoclonal antibody therapy for malignancies.FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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