Recombinant Human KRAS (G12C),BR

别名： Ki-Ras;c-K-ras;KRAS2;RASK2;CFC2
中文名称: Recombinant Human KRAS (G12C)
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： K-Ras belongs to the small GTPase superfamily，Ras family.As other members of the Ras family，K-Ras is a GTPase and is an early player in many signal transduction pathways.It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus.K-Ras functions as a molecular on/off switch.Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.Plays an important role in the regulation of cell proliferation.Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.Besides essential function in normal tissue signaling，the mutation of a K-Ras gene is an essential step in the development of many cancers.Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome.Somatic K-Ras mutations are found at high rates in Leukemias，colon cancer，pancreatic cancer and lung cancer.
来源： E.coli

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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