Anti-RFFL Polyclonal Antibody,BR

英文名称： Anti-RFFL Polyclonal Antibody
中文名称： E3泛素-蛋白连接酶rififylin抗体
规格： 50ul ; 100ul ; 20ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Human
应用： IHC-P
稀释比例： IHC-P 1:25-100.

靶标： RFFL
别名： RFFL;CARP-2;CARP2;FRING;RIFIFYLIN;RNF189;RNF34L;E3 ubiquitin-protein ligase rififylin
背景说明： E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Swiss Prot： Q8WZ73
Gene ID： 117584
亚细胞定位： Cytoplasm
研究领域： 肿瘤&癌症 ; 免疫学
免疫原： Recombinant protein of human RFFLPublic Immunogen Range 1-327aa
理论分子量： 37/40/41kDa

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输

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