猪基质金属蛋白酶1Elisayabo官网手机版 盒,BR

中文名称： 猪基质金属蛋白酶1检测yabo官网手机版 盒
英文名称： Porcine MMP-1 ELISA Kit
别名： CLGmatrix metalloprotease 1; CLGN; Fibroblast collagenase; interstitial collagenase; matrix metallopeptidase 1 (interstitial collagenase); Matrix metalloproteinase-1; MMP1; MMP-1
储存条件： 2-8℃，6 months
规格： 48T ; 96T
检测目标： MMP-1
样品类型： 血清/血浆/细胞培养上清
反应性： Porcine
应用： ELISA
定量/定性： 定量检测
检测范围： 125-8000pg/mL
灵敏度： 25pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Swiss Prot： P21692
Gene ID： 397320
背景说明： Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-1 (interstitial collagenase), can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, alpha ‑1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL-1 beta, IGF-BP3, IGF-BP5, pro MMP-2 and pro MMP-9. A significant role of MMP-1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into ¾, ¼ fragments. However, as the list of substrates above illustrates, the role of MMP-1 is more diverse than originally envisaged, and may involve enzyme cascades, cytokine regulation and cell surface molecule modulation. MMP-1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. Structurally, MMP-1 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain.

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