猪Toll样受体9Elisayabo官网手机版 盒,BR

中文名称： 猪Toll样受体9检测yabo官网手机版 盒
英文名称： Porcine TLR9 ELISA Kit
别名： CD289 antigen; CD289; TLR9; toll-like receptor 9
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： TLR9
样品类型： 血清/血浆/细胞培养上清
反应性： Porcine
应用： ELISA
定量/定性： 定量检测
检测范围： 125-8000pg/mL
灵敏度： 13pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Swiss Prot： Q5I2M3
背景说明： TLR9 (Toll receptor 9; also CD289) is a 145-150 kDa member of the Toll-like receptor family of molecules. It is expressed by colonic epithelium, CD123+ plasmacytoid dendritic cells, and transitional B cells, and responds to unmethylated DNA CpG motifs that exhibit either a GTCGTT sequence (in human), or a GACGTT sequence (in mouse). TLR9 is found in the ER, and translocates to either the cell membrane, or to lysosomes where it binds bacterial DNA. Precursor human TLR9 is a type I transmembrane protein 1032 amino acids (aa) in length. It possesses a 793 aa extracellular region that contains 26 LRRs (aa 26-818), plus a 193 aa cytoplasmic domain. The full-length 150 kDa form is suggested to be ligand-binding but nonsignaling. The active form is believed to be an 80 kDa cleavage product found in the endosome compartment. There are multiple splice forms. One contains a deletion of aa 2-16, a second possesses an alternate start site at Met58, while a third and fourth show alternative start sites aa 23 and 24 upstream of the standard site. Over aa 64-189, human TLR9 shares 76% aa identity with mouse TLR9.

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