小鼠表皮生长因子受体检测yabo官网手机版 盒,BR

中文名称： 小鼠表皮生长因子受体检测yabo官网手机版 盒
英文名称： Mouse EGFR ELISA Kit
别名： Epidermal Growth Factor Receptor; cell growth inhibiting protein; EGFR; ErbB; ErbB1; ERBB1PIG61; HER1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
储存条件： 2-8℃，6 months
规格： 48T ; 96T
检测目标： EGFR
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
检测范围： 78.13-5000pg/mL
灵敏度： 39pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%
反应时间： 3h15min

Swiss Prot： Q01279
Gene ID： 13649
背景说明： The EGF R subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER-1, ErbB1, or ErbB), ErbB2 (Neu, HER-2), ErbB3 (HER-3), and ErbB4 (HER-4). All family members are type I transmembrane glycoproteins with an extracellular ligand binding domain containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain followed by multiple tyrosine autophosphorylation sites. The human EGF R cDNA encodes a 1210 amino acid (aa) precursor with a 24 aa signal peptide, a 621 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 542 aa cytoplasmic domain. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse. Within the ECD, human EGF R shares 88% aa sequence identity with mouse and rat EGF R. It shares 43% - 44% aa sequence identity with the ECD of human ErbB2, ErbB3, and ErbB4. EGF R binds a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, and epigen. Ligand binding induces EGF R homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, heterodimerization tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGF R is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs.

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