小鼠前列腺酸性磷酸酶检测yabo官网手机版 盒,BR

中文名称： 小鼠前列腺酸性磷酸酶检测yabo官网手机版 盒
英文名称： Mouse Prostatic Acid Phosphatase ELISA Kit
别名： 5' -NT; 5' -nucleotidase; ACP3; PAP; Prostatic acid phosphatase; TMPase
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： Prostatic Acid Phosphatase
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
检测范围： 312.5-20000pg/mL
灵敏度： 156.25pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%
反应时间： 3h15min

Swiss Prot： Q8CE08
Gene ID： 56318
背景说明： Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.

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