小鼠表面活性蛋白D检测yabo官网手机版 盒,BR

中文名称： 小鼠表面活性蛋白D检测yabo官网手机版 盒
英文名称： Mouse SP-D ELISA Kit
别名： Surfactant protein D; Collectin 7; Lung surfactant protein D; PSPD; PSP-D; SFTP4; SFTPD; SPD; SP-D; SP-Dpulmonary surfactant apoprotein; surfactant protein D; surfactant-associated protein, pulmonary 4
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： SP-D
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
检测范围： 62.5-4000pg/mL
灵敏度： 31.25pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Swiss Prot： P50404
Gene ID： 20390
背景说明： Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides, it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

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