Recombinant Human TIGIT/VSTM3,BR

别名： T-cell immunoreceptor with Ig and ITIM domains;;VSIG9;VSTM3;TIGIT;V-set and transmembrane domain-containing protein 3;V-set and immunoglobulin domain-containing protein 9
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

背景说明： T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins.TIGIT is expressed on NK cells and subsets of activated，memory and regulatory T cells，and particularly on follicular helper T cells within secondary lymphoid organs.It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium.Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation，while NK cell TIGIT ligation blocks NK cell cytotoxicity.Through CD155 and Nectin-2，which also interact with DNAM-1/CD226 and CD96/Tactile，TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other.In particular，TIGIT binding to CD155 can antagonize the effects of DNAM1.
来源： Human cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human T cell Immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Met22-Pro141 is expressed with a 6His tag at the C-terminus.

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