Recombinant Human R-spondin-1/RSPO1,BR

别名： RSPO1;R-spondin1;RP11-566C13.1;CRISTIN3;FLJ40906;RSPO Rspo1;R-spondin;Rspondin;RP23-325M14.2;Roof plate-specific spondin-1
英文名称： Recombinant Human R-spondin-1/RSPO1
中文名称： 重组人R-spondin-1/RSPO1
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件： 冷藏运输

背景说明： RSPO1 is a secreted protein，containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family.RSPO1 is required for the early development of gonads，regardless of sex.It has been found in mice only eleven days after fertilization.To induce cell proliferation，it acts synergistically with WNT4.They help stabilize β catenin，which activates downstream targets.RSPO1 is necessary in female sex development.It augments the WNT/β catenin pathway to oppose male sex development.In critical gonadal stages，between six and nine weeks after fertilization，the ovaries upregulate it while the testes downregulate it.RSPO1 can potentially aid in the treatment of mucositis，which is characterized by inflammation of the oral cavity.This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
来源： Human cells

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

Recombinant Human R-spondin-1 is produced by our Mammalian expression system and the target gene encoding Arg31-Ala263 is expressed with a 6His tag at the C-terminus.

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