Recombinant Human BTLA/B-andT-lymphocyte attenuator/CD272(Fc fusion),BR

别名： B- and T-Lymphocyte Attenuator;B- and T-Lymphocyte-Associated Protein;CD272;BTLA
英文名称： Recombinant Human BTLA/B-andT-lymphocyte attenuator/CD272(Fc fusion)
中文名称： 重组人BTLA/B-andT-lymphocyte attenuator/CD272(Fc fusion)
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件： 冷藏运输

背景说明： B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain.BTLA expression is induced during activation of T cells，and BTLA remains expressed on Th1 cells but not Th2 cells.Like PD1 and CTLA4，BTLA interacts with a B7 homolog，B7H4.However，unlike PD-1 and CTLA-4，BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R)，not just the B7 family of cell surface receptors.BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response.BTLA also is a ligand for tumor necrosis factor (receptor) superfamily，member 14 (TNFRSF14)，also known as herpes virus entry mediator (HVEM).BTLA-HVEM complexes negatively regulate T-cell immune responses.
来源： Human cells

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human B- and T-Lymphocyte Attenuator is produced by our Mammalian expression system and the target gene encoding Lys31-Leu150 is expressed with a Fc tag at the C-terminus.

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