Recombinant Human IL-31,BR

别名： Interleukin-31;IL-31;IL31
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

背景说明： Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure.It shares several structural and functional characteristics with IL-6，Oncostatin M，LIF，and Cardiotrophin-1.Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein.Human and mouse IL-31 share 24% sequence identity in the mature region.IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2).IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ).The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes.GPL/OSMR signaling is a strong activator of STAT3 and STAT5，and can also activate STAT1，Jak1，and Jak2 signaling pathways.IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
来源： E.coli

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human Interleukin-31 is produced by our E.coli expression system and the target gene encoding Ser24-Thr164 is expressed.

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